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The Main Application of Polyethylene Glycol (II)

Its weakness is:

  • The effective concentration range is narrow (50%~55%), but it is more toxic to cells at this time.
  • The cell fusion process cannot be observed under the microscope.
  • The frequency of inducing hybrid cells is low (about 1×10-5). In addition to being used as a melting accelerator, it can also be used to promote the uptake of exogenous transformed DNA by yeasts, and can be used as a precipitant in clinical chemistry and as an osmotic concentration agent for aqueous solutions or suspensions such as serum.

Other applications:

Used as analytical reagent, also used in the pharmaceutical industry

Used in softeners, lubricants, etc.

Used as a matrix in medicine and cosmetics, as a dispersant, lubricant, emulsifier, etc. in rubber, metal processing, and pesticide industries

Organic synthesis medium, moisturizer for daily cosmetics industry, inorganic salt solubilizer, viscosity modifier, etc.

Used as flocculant, fluid antifriction agent, textile sizing agent, retention and drainage aid, binding agent, thickener, and denture fixative, etc.

Used in cosmetics, pharmaceuticals, chemical fiber, rubber, paper, paint, electroplating

Used as a mold agent, metal wire drawing, stamping and forming lubricant, paper industry lubricant, cutting fluid, grinding fluid cooling lubricant, polishing agent, etc.

Used as PVC lubricant, masterbatch additive, textile softener, pigment dispersant, etc.

As a papermaking additive, it can increase the retention rate of fillers and fine fibers. When the relative molecular mass is above 3 million, it has good dispersibility, certain wettability, drag reduction and pyrolysis. It is an effective deflocculant. Adding to the pulping can increase the viscosity of the slurry, prevent the fibers from adhering to each other, improve the uniformity of the paper, reduce the power consumption of beating, and increase the physical strength.

PEG-200: It can be used as a medium for organic synthesis and a heat carrier with higher requirements. It can be used as a humectant, inorganic salt solubilizer, and viscosity regulator in the daily chemical industry; it can be used as a softener and antistatic in the textile industry. Agent; used as a wetting agent in the papermaking and pesticide industries.

PEG-400: PEG-400 is most suitable for soft capsules. Because PEG400 is a liquid, it has wide compatibility with various solvents and is a good solvent and solubilizer. It is widely used in liquid preparations, such as oral liquids and eye drops. When vegetable oils are not suitable for active ingredient carriers, PEG is the material of choice. This is mainly because PEG is stable and not easily deteriorated. Injections containing PEG are safe and stable when heated to 150 degrees Celsius. In addition, it can be mixed with high molecular weight (PEG), and the mixture has good solubility and good compatibility with drugs.

PEG-400, 600, 800: used as a base for medicine and cosmetics, as a lubricant and wetting agent in the rubber industry and textile industry. PEG-600 added to the electrolyte in the metal industry can enhance the grinding effect and enhance the gloss of the metal surface.

PEG-1450, 3350: PEG-1450, 3350 are most suitable for ointments, suppositories, and creams. Due to the high water solubility and wide melting point range, PEG1450 and 3350 can be used alone or mixed to produce a long storage time and a melting point range that meets the requirements of drugs and physical effects. Suppositories using PEG bases are less irritating than traditional oil bases.

PEG-1000, PEG-1500: used as a matrix or lubricant and softener in the pharmaceutical, textile and cosmetic industries; used as a dispersant in the coating industry to improve the water dispersibility and flexibility of the resin, the dosage is 10-30 %; In the ink, it can improve the dissolving ability of the dye and reduce its volatility. It is especially suitable for wax paper and stamp ink. It can also be used for adjusting ink viscosity in ballpoint pen ink; as a dispersant in the rubber industry to promote vulcanization, used as a dispersant for carbon black filler.

PEG-2000, 3000: used as metal processing mold agent, metal drawing, stamping or forming lubricant and cutting fluid, grinding cooling lubricating polishing agent, welding agent, etc.; used as a lubricant in the paper industry, etc., and also used as a heat Melt adhesive to increase rapid rewetting ability.

PEG-4000, 6000, 8000: PEG-4000, 6000, 8000 are used in tablets, capsules, film coatings, dripping pills, suppositories, etc.

PEG-4000 and 6000 are used as excipients in the pharmaceutical industry for the preparation of suppositories and ointments; used as a finishing agent in the paper industry to increase the gloss and smoothness of paper; as an additive in the rubber industry to increase the lubrication of rubber products Properties and plasticity, reduce power consumption during processing, and extend the service life of rubber products.

Used as a matrix in the production of pharmaceuticals and cosmetics industries to adjust viscosity and melting point; used as a lubricant and cooling agent in the rubber and metal processing industries; as a dispersant and emulsifier in the industrial production of pesticides and pigments; Used as antistatic agent and lubricant in textile industry.

Due to the plasticity of PEG and its ability to release drugs from tablets in the process of making tablets, high molecular weight PEG (PEG-4000, PEG-6000, PEG-8000) is very useful as a binder for making tablets. PEG can make the surface of the tablet shiny and smooth, while not easily damaged. In addition, a small amount of high molecular weight PEG (PEG-4000, PEG-6000, PEG-8000) can prevent the adhesion between sugar-coated tablets and the adhesion between medicine bottles.

Cell fusion technology mainly adopts polyethylene glycol: polyethylene glycol (PEG) molecules can change the biomembrane structure of various types of cells, so that lipid molecules in the plasma membrane at the contact point of two cells are evacuated and reorganized. The mutual affinity of the bilayer plasma membrane and the interaction of the surface tension between the cells cause the cells to fuse to form hybrid cells. By culturing the hybrid cells (cytoplasmic hybrids), some special hybrid plants can be obtained.

Uses in molecular biology: PEG can induce the aggregation of macromolecules in aqueous solutions. There are many uses in molecular cloning, including: 1. Precipitation of DNA according to molecular size; 2. Precipitation and purification of phage particles; 3. Hybridization, blunt-end ligation of DNA molecules and increase of complementary nucleic acid when DNA end-labeling with T4 polynuclease kinase Chain binding efficiency. 4. Fusion of cells or bacterial protoplasts.

Polyethylene glycol series products can be used as raw materials for ester surfactants.

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