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What’s the difference between monodisperse and polydisperse PEG?

Polyethylene glycol (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. It is non-toxic, FDA-approved, usually nonimmunogenic, and is often used in many biomedical applications including bioconjugation, drug delivery,  surface functionalization, and tissue engineering. Bioconjugation with PEG (also called PEGylation) is the covalent conjugation of drug targets such as peptides, proteins, or oligonucleotides with PEG which can effectively improve their water-solubility and circulation half-life of medicines, resulting in enhanced safety and therapy effects .  In drug delivery, PEGs can be used as linkers for antibody-drug conjugates (ADCs) or as a surface coating on nanoparticles to improve systemic drug delivery.

What’s the difference between monodisperse and polydisperse PEG?​

At present, most of the polyethylene glycol compounds supplied on the market are polymers formed by the polymerization of ethylene glycol. The molecular weight of polydisperse PEG is uncertain, and distributed in a certain range. Often polydispersity index (PDI) is used to determine how narrow the molecular weight distribution is. On the country,Monodisperse PEG refers to a polyethylene glycol (PEG) with a precise, discrete molecular weight (ie, with a fixed molecular weight rather than a range).

According to some researches, the use of polydisperse PEG linkers in drug development has led to problems in biological applications due to steric hindrance and binding. Thus, monodispersed PEG linkers have become more commercially viable now, which has been found to be beneficial in drug design, specifically in small molecule drugs. The introduction of monodispersed PEG linkers to small molecule drugs increases the drug’s solubility and molecular weight, which extend drug half-life in the body.

One of Biochempeg‘s goals in manufacturing PEG linkers is to ensure high quality products for worldwide clients. We aim to manufacture monodisperse PEG linkers with high purity and a single molecular weight.


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